Key result
High glucose inhibits the maturation of cardiomyocytes by promoting nucleotide biosynthesis through the pentose phosphate pathway, providing a possible mechanism for congenital heart disease.
Why the study?
Does high glucose exposure inhibit cardiac muscle maturation in developing cardiomyocytes?
Does high glucose exposure inhibit cardiac muscle maturation in developing cardiomyocytes?
High glucose suppresses cardiac maturation by promoting nucleotide biosynthesis, providing a possible mechanistic basis for congenital heart disease in diabetic pregnancy.
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Hyperglycemia may impair fetal cardiomyocyte maturation; this level-5 study leaves open its role in congenital heart disease.
Nakano et al. (2017) studied Congenital heart disease in diabetic pregnancy. High glucose was evaluated on Cardiomyocyte maturation. High glucose inhibits the maturation of cardiomyocytes by promoting nucleotide biosynthesis through the pentose phosphate pathway, providing a possible mechanism for congenital heart disease.
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