PURPOSE: To compare two starting doses (50 µg vs. 100 µg) of a titrated low-dose misoprostol regimen after mifepristone for second-trimester abortion in women with one prior cesarean and premature rupture of membranes (PROM). MATERIALS AND METHODS: -26 weeks) and initial doses using t-tests, chi-square tests, and multivariable regression. RESULTS: Induction-to-abortion time was similar across groups (15.4-18.6 h). Total misoprostol dose was significantly lower with 50 µg (372-518 µg) than 100 µg (778-878 µg). No uterine rupture or severe hemorrhage occurred. Success rates within 48 h were high (95.7%-97%) and comparable. CONCLUSIONS: The 50 µg starting dose significantly reduced total drug exposure, with similarly high success rates and no observed uterine ruptures. These findings suggest a potentially safe, individualized approach, but require confirmation in prospective randomized trials against standard higher-dose regimens.
Wang et al. (Wed,) studied this question.
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