Fading Faces: Orofacial Findings in Parry‐Romberg Syndrome—Clinical Case Series

ABSTRACT Introduction Parry–Romberg syndrome (PRS), or idiopathic progressive facial hemiatrophy, is an extraordinary condition marked by progressive craniofacial and neurocutaneous atrophy, resulting in hemifacial atrophy that becomes noticeable in adult life. Parry–Romberg syndrome is frequently ignored because of its PRS features, which overlap with linear scleroderma and Barraquer–Simon syndrome, making it diagnostically challenging. The progressive hemiatrophy of the face is an unusual phase of development marked by unilateral facial atrophy that, over the years, slowly progresses to stabilisation or a burnout phase. The orodental features of Parry–Romberg syndrome include jaw hypoplasia with decreased ramus height, short roots, and delayed eruption. Objectives The case series highlights a number of clinically noteworthy cases, emphasising their radiological and clinical characteristics, as well as diagnostic difficulties. The case series aims to highlight unusual presentations, enhance identification of significant results, and address their applicability in standard clinical practice. Additionally, it aims to disseminate beneficial insights that could support early diagnosis, suitable treatment planning, and improved patient outcomes. Case Series The case series presents a singular adult‐juvenile couple case of Parry–Romberg syndrome in a 23‐year‐old male and a 17‐year‐old female, which included orofacial clinical findings. These cases focus on the significant challenges in diagnosing PRS, including healthcare problems arising from its features, such as unilateral facial asymmetry distorting orofacial features, one‐sided facial hair loss, augmenting the uneven appearance, and discomfort with sociocultural standards. Conclusion Progressive hemifacial atrophy of the skin, muscles, subcutaneous tissues, cartilage, and bone, short roots, and impacted teeth make this condition rare and complex to diagnose. An interdisciplinary team of dermatologists, orthodontists, maxillofacial surgeons, neurologists, and plastic surgeons is essential for the integrated diagnosis and treatment of the condition, given its extensive overlapping clinical features and variations.