Abstract Electrical stimulation for diabetic wound healing predominantly relies on wired power supplies, which not only increase the risk of secondary infection and complicate clinical operation but may also misalign with the endogenous bioelectric field (EF), collectively limiting effective tissue repair. To address the above limitations, we developed a portable hydrogel dressing wirelessly powered by near-field communication (NFC) through mobile phones, which produces electrical stimulation in precise alignment with the EF and thus effectively facilitates diabetic wound repair. Mechanistic studies reveal that the reconstructed directional biomimetic electric field significantly activates the Phosphatidylinositol 3-kinase/AKT (PI3K/AKT) signaling pathway within the wound tissue microenvironment, thereby reshaping the immune response pattern and restoring immune homeostasis. Simultaneously, the hydrogel dressing efficiently promotes the migration and proliferation of epidermal cells and induces neovascularization, providing essential structural support for wound repair. By integrating wireless NFC technology with directional bioelectric field therapy, this study provides a novel paradigm for the repair of clinically refractory infected diabetic wounds and demonstrates significant value for clinical translation and application.
Zong et al. (2026) studied this question.