applications, particularly with the development of prodrug strategies. This work introduces the ethynylated biarylbutanamide (EBB) group, which was designed to undergo gold-catalyzed hydrothiolation, cyclization, and hydrolysis to release amines under mild physiological conditions. To highlight its application for anticancer prodrug therapies, this study then utilized lectin-directed artificial metalloenzymes for the gold-catalyzed activation of an EBB-masked prodrug against targeted hypersialylated cancer cells.
Huang et al. (Wed,) studied this question.
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