Study of the effects of Naphthalan oil, White Naphthalan oil, and Artra ointment on blood lipoproteins in rats with experimental osteoarthritis

Osteoarthritis is a chronic condition characterized by the degeneration of articular cartilage and increased inflammatory processes. It is well established that the progression of osteoarthritis leads to increased levels of lipid peroxidation (LPO) products in the cells and tissues of the organism. As a result, structural and functional impairments occur in the membranes of periarticular cells. This study aimed to evaluate the effects of Naftalan oil, White Naftalan oil, and Artra ointment on plasma lipid spectrum parameters in an experimental model of osteoarthritis (OA). In this experiment, conducted on white rats, OA was induced, and the effects of various therapeutic agents on lipoprotein levels, including total cholesterol, low-density lipoproteins, high-density lipoproteins, very low-density lipoproteins, and triglycerides, were investigated. The results revealed that the lipid profile was significantly altered during OA, and these changes were partially reversed following treatment. Artra ointment exhibited the greatest efficacy in normalizing lipid parameters, whereas White Naftalan oil was notable for its antioxidant and anti-inflammatory properties. The findings of this study suggest that these natural agents may exert beneficial effects on lipid metabolism, reduce oxidative stress and inflammation, and therefore hold therapeutic potential in the treatment of osteoarthritis.