Research uncovers the genetic diversity and regulatory mechanisms of NOTCH2NL, implicating its role in human brain development.
Segmental duplications are key drivers of evolutionary innovation but are also particularly challenging to study. In this issue, Real et al. resolve the genetic diversity, structural history, and regulatory landscape of the human-specific NOTCH2NL gene family, a likely contributor to human cortical brain expansion.
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Egyes et al. (2026) studied this question.
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