Kidney Transplant after Clearing Anti-HLA Antibodies with CD19 Car T Cells

Brian Huntly

doi:10.17863/cam.130902

June 4, 2026Open Access

Kidney Transplant after Clearing Anti-HLA Antibodies with CD19 Car T Cells

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Key Points

This research aims to address the challenge of HLA sensitization in kidney transplantation by exploring the use of CD19 CAR T cell therapy.
Clinical course of a broadly HLA-sensitized patient was monitored.
Anti-CD19 CAR T cell therapy was administered prior to transplantation.
Outcomes were assessed post-transplantation for graft success and rejection rates.
Successful kidney transplantation was achieved following anti-CD19 CAR T cell therapy.
The patient showed no signs of antibody-mediated rejection after the procedure.
The approach may reduce the need for intensified immunosuppression associated with HLA antibodies.

Implication

Demonstrates successful kidney transplantation in sensitized patient, indicating an innovative treatment approach.

Abstract

HLA sensitization remains a major barrier to kidney transplantation.1,2 Transplantation in the presence of donor-specific HLA antibodies confers a high risk of antibody-mediated rejection (AMR), often necessitating intensified immunosuppression and resulting in premature graft loss. We report the clinical course of a broadly HLA-sensitized patient in whom anti-CD19 CAR T cell therapy enabled successful kidney transplantation.

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Cite This Study

Brian Huntly (2026) studied this question.

synapsesocial.com/papers/6a2ba2f68101cf8926f01c0c https://doi.org/10.17863/cam.130902

View Full Paper

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Kidney Transplant after Clearing Anti-HLA Antibodies with CD19 Car T Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

Kidney Transplant after Clearing Anti-HLA Antibodies with CD19 Car T Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

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