Analysis of the Degradation Pathways, Cytotoxicity, and Antimicrobial Properties of Block Amphiphilic Aliphatic Polyesters Containing Amine and Hydroxyl Groups

This study evaluates the antibacterial activity, cytotoxicity, and hydrolytic degradation of block poly(esteramine)s synthesized via the copolymerization of L‐lactide and glycolide in the presence of a macroinitiator derived from DEA, HEDEA, and Dimethyl L‐tartrate. The findings highlight the significant potential of these polymers for biomedical use. Under simulated physiological conditions, the copolymers exhibit rapid degradation, reaching total hydrolysis within 14 to 30 days. The degradation time strongly depends on the copolymer composition. The inclusion of hydrophilic blocks containing amino groups accelerates this process, as these groups exert a catalytic effect on ester bond hydrolysis within both the polyesteramine and PLAGA segments.