Review assesses BRUE 2.0 criteria for risk evaluation in infants, suggesting improved diagnosis differentiation.
Most (96%) patients presenting with brief resolved unexplained events (BRUE, formerly apparent life-threatening event or ALTE) do not have a serious underlying diagnosis*. The AAP guidelines do not help differentiate infants with such diagnoses from those without. The BRUE 2.0 tool is designed to determine which infants presenting with BRUE are at low risk for having a serious underlying diagnosis as well as those who are at risk for recurrent events.
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Derek Chi Fung Tam (2026) studied this question.
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