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June 12, 2026Open Access

Polymorphism in Antidiabetic Drugs: Analytical Characterization and its Impact on Pharmaceutical Performance

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Authors

SBSwati D. Meshram, Vaishnavi G. Darne, Abhay S. Satpute, Disha M. Dhabarde, Dr. Jagdish Baheti

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Overview

Review examines how polymorphism affects antidiabetic drug performance and analysis techniques used.

Key Points

  • The review aims to evaluate the significance of polymorphs in antidiabetic drugs, focusing on metformin and dapagliflozin.
  • Analytical techniques discussed include powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FTIR), and solid-state nuclear magnetic resonance (ss-NMR).
  • The review assesses the strengths and limitations of these methods.
  • Emphasizes the importance of controlling polymorphic forms for optimal therapeutic activity.
  • Metformin requires strict control of its solid-state form for maintaining therapeutic efficacy.
  • Dapagliflozin's polymorphic changes can negatively impact stability during processing and storage.
  • Effective detection and control of polymorphs are crucial for ensuring drug safety and performance.

Cite This Study

Swati D. Meshram, Vaishnavi G. Darne, Abhay S. Satpute, Disha M. Dhabarde, Dr. Jagdish Baheti (2026) studied this question.

synapsesocial.com/papers/6a2ba3748101cf8926f0215fhttps://doi.org/10.5281/zenodo.20626804
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