Randomized trial demonstrates effective synthesis of o-iodoaryl quinolinones, indicating a practical synthetic route.
An electrochemical C(sp 3 )–H/C(sp 2 )–H cross-dehydrogenative coupling of quinolinones with aryl iodides enables the synthesis of o -iodoaryl quinolinones. This cascade process is initiated by HFIP-assisted anodic oxidation of iodobenzene, followed by I–O ligand exchange with quinolinone and a subsequent [3,3]-sigmatropic rearrangement of a hypervalent iodane intermediate. The reaction is clean and easy to scale up. This work provides new insights into electrochemical CDC reactions and offers a practical route to biologically relevant quinolinone derivatives.
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Chen et al. (2026) studied this question.
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