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Abstract N 6 -methyladenosine (m 6 A) represents the most prevalent internal and reversible modification on RNAs. Different cell types display their unique m 6 A profiles, which are determined by the functions of m 6 A writers and erasers. M 6 A modifications lead to different outcomes such as decay, stabilization, or transport of the RNAs. The m 6 A-encoded epigenetic information is interpreted by m 6 A readers and their interacting proteins. M 6 A readers are essential for different biological processes, and the defects in m 6 A readers have been discovered in diverse diseases. Here, we review the latest advances in the roles of m 6 A readers in development and diseases. These recent studies not only highlight the importance of m 6 A readers in regulating cell fate transitions, but also point to the potential application of drugs targeting m 6 A readers in diseases.
Chen et al. (Sat,) studied this question.