The prevalence of hemoglobinopathies and hemolytic anemias strongly correlated with global pulmonary arterial hypertension incidence (R = 0.61, P = 7.70 × 10⁻²²).
Observational
Hemolysis-associated disorders, particularly G6PD trait and vitamin A deficiency, are strongly associated with the global incidence of pulmonary arterial hypertension, highlighting an underrecognized driver of the disease.
Effect estimate: R = 0.61
p-value: p=7.70 × 10⁻²²
Pulmonary arterial hypertension (PAH) is a progressive cardiovascular disease with an increasing global burden. Although hemolytic disorders are established causes of PAH, their contribution to the global PAH burden remains unclear. This study aimed to evaluate the association between hemolysis-associated disorders and PAH incidence and to identify the relative contribution of hemolytic disorder subtypes compared with socio-demographic factors.
Rebecca Lewandowski (Thu,) conducted a observational in Pulmonary arterial hypertension. Hemolysis-associated disorders was evaluated on Correlation between PAH age-standardized incidence rate and prevalence of hemoglobinopathies and hemolytic anemias (R = 0.61, p=7.70 × 10⁻²²). The prevalence of hemoglobinopathies and hemolytic anemias strongly correlated with global pulmonary arterial hypertension incidence (R = 0.61, P = 7.70 × 10⁻²²).