Key result
Cardiac rehabilitation improves VO2peak overall but yields smaller gains in non-dilated LV cardiomyopathy versus CAD.
Why the study?
Cardiac rehabilitation improves exercise capacity, ventilatory efficiency, and quality of life in coronary artery disease and heart failure, but evidence in non-ischaemic cardiomyopathies remains limited.
Does a centre-based cardiac rehabilitation programme improve peak oxygen uptake and functional capacity in patients with non-ischaemic cardiomyopathies?
Population
606 consecutive patients completing a centre-based cardiac rehabilitation programme
Comparison
CAD vs DCM vs NDLVC vs HCM
Design
Retrospective cohort study
Authors
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May support CR referral in non-ischaemic cardiomyopathy; hypothesis-generating for etiology-specific responses.
Cohort (n=606)
No
Does a centre-based cardiac rehabilitation programme improve peak oxygen uptake and functional capacity in patients with non-ischaemic cardiomyopathies?
Absolute Event Rate: 0.8% vs 3%
p-value: p=0.003
Cardiac rehabilitation provides significant functional, structural, and psychosocial benefits in patients with non-ischaemic cardiomyopathies, supporting its routine integration into their clinical management.
Stiefel et al. (2026) conducted a cohort in Non-ischaemic cardiomyopathies and coronary artery disease (n=606). Cardiac rehabilitation vs. Coronary artery disease (for subgroup comparisons) was evaluated on change in peak oxygen uptake (VO2peak) (p=0.003). Cardiac rehabilitation improved peak oxygen uptake overall (+2.7 mL/kg/min; p<0.001), with attenuated gains in non-dilated left ventricular cardiomyopathy compared to CAD (+0.8 vs +3.0; p=0.003).
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