Key result
Cardiac rehab increases fibrinolysis in men but not women with CAD, despite their higher hemostatic potential.
Why the study?
The biological basis of sex differences in CAD remains unclear, and the impact of cardiac rehabilitation on hemostasis has not yet been elucidated.
Does a structured cardiac rehabilitation programme differentially affect hemostatic potentials in men versus women with coronary artery disease after acute myocardial infarction?
Population
107 patients referred for cardiac rehabilitation within 90 days after acute myocardial infarction
Comparison
Men vs women before and after cardiac rehabilitation
Design
Observational study
Follow-up
After completion of rehabilitation
Authors
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Women post-MI show persistently higher hemostatic potential than men after rehabilitation; extends RCT evidence on sex-specific coagulation and fibrinolytic responses.
Observational (n=107)
Does a structured cardiac rehabilitation programme differentially affect hemostatic potentials in men versus women with coronary artery disease after acute myocardial infarction?
Absolute Event Rate: 9.5% vs 7.8%
p-value: p=0.013
Cardiac rehabilitation increases fibrinolysis in men but not in women after acute myocardial infarction, highlighting sex-specific differences in hemostasis and CAD pathophysiology.
Kobale et al. (2026) conducted an observational in Coronary artery disease (CAD) after acute myocardial infarction (n=107). Female sex vs. Male sex was evaluated on Overall hemostatic potential (OHP) at baseline (p=0.013). Women with coronary artery disease had higher baseline overall hemostatic potential than men (9.5 vs 7.8; p=0.013), and cardiac rehabilitation increased fibrinolysis in men but not in women.