Key result
The 3.5-angstrom crystal structure of RF2 bound to the 70S ribosome reveals how RF2 specifically recognizes the UGA stop codon and suggests a model for the catalytic role of the GGQ motif.
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Advances structural models of termination; leaves open functional validation and therapeutic translation.
Weixlbaumer et al. (2008) studied this question. The 3.5-angstrom crystal structure of RF2 bound to the 70S ribosome reveals how RF2 specifically recognizes the UGA stop codon and suggests a model for the catalytic role of the GGQ motif.
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