Key result
Native T1 and post-contrast T1 mapping reliably differentiated between healthy myocardium, acute inflammatory infiltrated myocardium, and chronic stages of experimental autoimmune myocarditis in rats.
Why the study?
Does pre- and post-contrast myocardial T1 mapping correlate with histological findings in an experimental rat model of autoimmune myocarditis?
Does pre- and post-contrast myocardial T1 mapping correlate with histological findings in an experimental rat model of autoimmune myocarditis?
Assessment of native and post-contrast T1 allows for reliable differentiation between healthy and inflamed myocardium, as well as between acute and chronic stages of myocarditis in a rat model.
T1 mapping may stage experimental myocarditis in rats; leaves open human validation before clinical use.
Background Magnetic resonance imaging as a noninvasive method offers diagnostic and prognostic information in myocarditis. T1 mapping techniques aim to overcome the limitations of late gadolinium enhancement to assess diffuse fibrosis and inflammatory infiltrates. Using an established animal model of myocarditis, the aim of this study was to measure myocardial T1 before the onset, and in the acute and chronic stages of the disease and to compare its course with histological and immunohistochemistry findings.
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Jeuthe et al. (2015) studied Experimental autoimmune myocarditis. Experimental autoimmune myocarditis vs. Healthy myocardium (baseline) was evaluated on Myocardial T1 (native and post-contrast) correlation with histology. Native T1 and post-contrast T1 mapping reliably differentiated between healthy myocardium, acute inflammatory infiltrated myocardium, and chronic stages of experimental autoimmune myocarditis in rats.
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