Key result
Plasma oxLDL levels positively correlated with circulating endothelial progenitor cells (r=0.46, p=0.02), which in turn positively correlated with coronary endothelial function (r=0.42, p=0.04).
Observational (n=33)
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In patients with stable CHD, plasma oxLDL is associated with increased circulating EPCs, which in turn correlate with coronary endothelial function, suggesting a host-repair response to endothelial injury.
OBJECTIVE: The balance between coronary endothelial dysfunction and repair is influenced by many protective and deleterious factors circulating in the blood. We studied the relationship between oxidised low-density lipoprotein (oxLDL), circulating endothelial progenitor cells (EPCs) and coronary endothelial function in patients with stable coronary heart disease (CHD). METHODS: 33 patients with stable CHD were studied. Plasma oxLDL was measured using ELISA, coronary endothelial function was assessed using intracoronary acetylcholine infusion and EPCs were quantified using flow cytometry for CD34(+)/KDR(+) cells. RESULTS: Plasma oxLDL correlated positively with the number of EPCs in the blood (r=0.46, p=0.02). There was a positive correlation between the number of circulating EPCs and coronary endothelial function (r=0.42, p=0.04). There was no significant correlation between oxLDL and coronary endothelial function. CONCLUSIONS: Plasma levels of oxLDL are associated with increased circulating EPCs in the blood of patients with CHD, which may reflect a host-repair response to endothelial injury. Patients with stable CHD had a high prevalence of coronary endothelial dysfunction, which was associated with lower numbers of circulating EPCs, suggesting a mechanistic link between endothelial dysfunction and the pathogenesis of atherosclerosis.
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Watt et al. (2016) conducted an observational in Stable coronary heart disease (CHD) (n=33). Plasma oxidised low-density lipoprotein (oxLDL) was evaluated on Correlation between plasma oxLDL and circulating endothelial progenitor cells (EPCs) (r=0.46, p=0.02). Plasma oxLDL levels positively correlated with circulating endothelial progenitor cells (r=0.46, p=0.02), which in turn positively correlated with coronary endothelial function (r=0.42, p=0.04).
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