Clinical correlation between platelet parameters and coronary artery lesions in pediatric Kawasaki disease

Objective To investigate the clinical correlation between the occurrence of coronary artery lesions and platelet levels in children with Kawasaki disease. Methods Propensity score matching was used to compare platelet parameters (PLT, MPV, PCT, PDW) between KD children and healthy controls. KD patients were divided into lesion and non-lesion groups according to coronary artery lesions. Harada score and multiple linear regression were applied to assess risk and correlation. Results No significant differences were observed in baseline data between the two groups ( P > 0.05), indicating comparability. Platelet parameters (PLT, MPV, PCT, PDW) in the experimental group were significantly higher than those in the control group (319.56 ± 26.17 vs. 201.56 ± 12.98; 8.94 ± 1.25 vs. 7.05 ± 1.13; 0.30 ± 0.08 vs. 0.13 ± 0.02; 20.75 ± 2.10 vs. 16.17 ± 1.89, all P < 0.05). The lesion group showed significantly higher platelet parameters than the non-lesion group (330.56 ± 31.89 vs. 303.89 ± 22.73; 9.41 ± 1.35 vs. 8.32 ± 1.19; 0.36 ± 0.06 vs. 0.24 ± 0.09; 22.47 ± 1.88 vs. 19.18 ± 1.76, all P < 0.05). The Harada score was significantly higher in the lesion group than in the non-lesion group (5.82 ± 1.39 vs. 4.17 ± 1.76, P < 0.05). Multivariate binary logistic regression analysis showed significant correlations between PLT, MPV, PCT, PDW and coronary artery lesions ( P < 0.05). Conclusion The occurrence of coronary artery lesions in children with Kawasaki disease is closely associated with platelet levels. These findings suggest that platelet parameters are associated with coronary artery lesions in children with Kawasaki disease. Further prospective studies are needed to validate their clinical utility in risk stratification and management.