Editorial: Psychological factors as determinants of medical conditions, volume III

volume emphasized their multidimensional and methodological articulation (Caputo et al., 2022), this third installment moves toward a more integrated and process-oriented perspective. Specifically, it underscores the role of psychological factors as dynamic processes that shape individual health trajectories over time, influencing both subjective experience and objective clinical outcomes.A growing body of evidence suggests that psychological processes, such as emotional regulation, cognitive functioning, personality organization, and health-related behaviors, operate in a deeply interconnected manner (Castelnuovo, Together, these studies underscore the need for increasingly sophisticated theoretical and methodological tools capable of capturing the complexity of mind-body interactions, in line with emerging perspectives on dynamic and non-linear systems in health research, with particular relevance for perceived quality of life across different clinical populations, including patients with severe hypersensitivity reactions (Ricciardi et al., 2024).Similarly, in conditions such as osteoporosis, psychological factors, including anxiety and broader clinical-psychological features, have been shown to influence objective health outcomes such as bone mineral density (Martino et al., 2021a;Martino et al., 2023).Taken together, the studies included in this volume reinforce the notion that psychological determinants of medical conditions should be conceptualized as dynamic, multilevel processes rather than isolated variables. Emotional, cognitive, and behavioral dimensions converge in shaping individual health trajectories, suggesting that an integrated and process-based approach is essential for both research and clinical practice.From a clinical perspective, these findings highlight the importance of incorporating psychological assessment and intervention into routine medical care. From a research standpoint, they call for the development of longitudinal and process-oriented models capable of capturing the evolving nature of psychological and somatic interactions. Ultimately, this integrated perspective may contribute to the development of more personalized and effective strategies for prevention, diagnosis, and treatment.It has been a great pleasure and honor to contribute to this Research Topic. We would like to sincerely thank all Authors for their valuable contributions, the Reviewers for their expertise and dedication, and the Frontiers Editorial and Developmental Staff for their continuous support. The richness and diversity of the contributions collected in this third volume not only consolidates the scientific relevance of this Research Topic but also opens promising directions for future research. In this regard, we look forward with great interest to further developments in this field, as the ongoing evolution of this series continues to deepen our understanding of the complex interplay between psychological factors and medical conditions.GM and CMV wrote the first draft of the manuscript and revised it critically. CMG and PS provided opinions on it. All authors read and approved the submitted version.