Childhood Adversity is Associated With Greater MS Symptoms, Disability Scores, and Epigenetic Changes in Pediatric and Adult-onset Multiple Sclerosis (P3-18.003)

Kimberly O’Neill; Bernard van der Veer; Leigh Charvet; Nadine Azmy; Steven Friedman; Jiyuan Hu; Kevin Lei; Robin Ortiz; Shayna Pehel; Yidan Shi; Anna Sosa; Kian Koh; Mirjana Maletic-Savatic; Lauren Krupp

doi:10.1212/wnl.0000000000213262

June 9, 2026Neurology

Childhood Adversity is Associated With Greater MS Symptoms, Disability Scores, and Epigenetic Changes in Pediatric and Adult-onset Multiple Sclerosis (P3-18.003)

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Key Points

This research investigates the relationship between childhood adversity and the severity of symptoms and disability in individuals with pediatric and adult-onset multiple sclerosis.
Assessed associations between childhood adversity and multiple sclerosis symptoms and disability scores in pediatric and adult-onset MS.
Conducted analyses to evaluate epigenetic changes related to childhood adversity.
Found greater MS symptoms and higher disability scores linked to childhood adversity in both pediatric and adult-onset MS populations.
Observed significant epigenetic changes associated with experiences of childhood adversity.

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Implication

Reveals associations between childhood adversity and greater MS symptoms and disability scores in youth and adults, suggesting significant impacts of early life stress.

Abstract

To describe associations between childhood adversity and multiple sclerosis (MS) symptoms and disability in early adulthood among pediatric-onset MS and adult-onset MS. Epigenetic changes are also assessed.

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O’Neill et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf32afaef96ed7f0559d5 https://doi.org/10.1212/wnl.0000000000213262

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Childhood Adversity is Associated With Greater MS Symptoms, Disability Scores, and Epigenetic Changes in Pediatric and Adult-onset Multiple Sclerosis (P3-18.003)

Key Points

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Implication

Abstract

Discussion

Cite This Study

Childhood Adversity is Associated With Greater MS Symptoms, Disability Scores, and Epigenetic Changes in Pediatric and Adult-onset Multiple Sclerosis (P3-18.003)

Key Points

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Implication

Abstract

Discussion

Cite This Study

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