Long-term Follow-up of Multiple Sclerosis Patients Treated With Cladribine Tablets as De-escalation Strategy From AntiCD20 (S40.009)

Claudio Gobbi; Rosaria Sacco; Giulio Disanto; Giulia Mallucci; Roberto Masciullo; Aleksandra Maleska; Jens Kuhle; Chiara Zecca

doi:10.1212/wnl.0000000000217042

June 9, 2026Neurology

Long-term Follow-up of Multiple Sclerosis Patients Treated With Cladribine Tablets as De-escalation Strategy From AntiCD20 (S40.009)

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Key Points

This investigation aims to assess the safety and effectiveness of transitioning multiple sclerosis patients from antiCD20 therapies to cladribine due to observed risks.
Long-term follow-up of multiple sclerosis patients
Switch from antiCD20 antibodies to cladribine
Assessment of safety concerning hypogammaglobulinemia and infection risk
Transition to cladribine demonstrates improved safety profiles for patients previously on antiCD20 therapies.
Patients showed reduced incidents of infections compared to ongoing antiCD20 treatment.

Implication

Evaluates safety and effectiveness of switching MS treatment to cladribine, highlighting its potential benefits.

Abstract

To investigate safety and effectiveness of switching MS patients from antiCD20 antibodies (antiCD20) to cladribine (CLAD) due to hypogammaglobulinemia and/or infection risk.

Discussion

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Cite This Study

Gobbi et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf32afaef96ed7f055a8e https://doi.org/10.1212/wnl.0000000000217042

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Long-term Follow-up of Multiple Sclerosis Patients Treated With Cladribine Tablets as De-escalation Strategy From AntiCD20 (S40.009)

Key Points

Implication

Abstract

Discussion

Cite This Study

Long-term Follow-up of Multiple Sclerosis Patients Treated With Cladribine Tablets as De-escalation Strategy From AntiCD20 (S40.009)

Key Points

Implication

Abstract

Discussion

Cite This Study

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