Clinical and Immunologic Safety Evaluation of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells in Parkinson’s Disease (P8-17.011)

Chiamaka Onuigbo; Jerome Saltarrelli; Juan Martinez Lemus; Emily Tharp; Scott Olson; Fabio Triolo; Joana Bianchi; Robert Ritter; Mya Schiess

doi:10.1212/wnl.0000000000215012

June 9, 2026Neurology

Clinical and Immunologic Safety Evaluation of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells in Parkinson’s Disease (P8-17.011)

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Key Points

This research aims to evaluate the safety of allogeneic bone marrow-derived mesenchymal stem cells in patients with Parkinson’s disease.
Conducted Phase I and Phase II clinical trials on allogeneic bone marrow-derived mesenchymal stem cells.
Administered cells intravenously to participants diagnosed with Parkinson’s disease.
Monitored for safety outcomes throughout the trials.
No serious adverse events were reported during the trials.
Participants exhibited stability in Parkinson’s disease symptoms.
Initial findings suggest allogeneic stem cells are safe for use.

Implication

Phase I and Phase II trials evaluate safety of allogeneic stem cells in Parkinson's disease, suggesting potential therapeutic benefits.

Abstract

To evaluate the safety of intravenous (IV) allogeneic bone marrow-derived mesenchymal stem cells (allo-hMSCs) in Parkinson’s disease (PD) across Phase I and Phase II clinical trials.

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Cite This Study

Onuigbo et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf34dfaef96ed7f055c8f https://doi.org/10.1212/wnl.0000000000215012

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Clinical and Immunologic Safety Evaluation of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells in Parkinson’s Disease (P8-17.011)

Key Points

Implication

Abstract

Discussion

Cite This Study

Clinical and Immunologic Safety Evaluation of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells in Parkinson’s Disease (P8-17.011)

Key Points

Implication

Abstract

Discussion

Cite This Study

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