Explores the RIP mechanism in eukaryotes, suggesting insights into ancient defense systems.
The repeat-induced point mutation (RIP) targets repeated sequences, such as transposable elements, in filamentous fungi. Host-transposable element coevolutionary dynamics have shaped taxonomically restricted eukaryotic defense systems, likely built on conserved ancestral mechanisms. Key questions surrounding homology recognition remain unresolved, and RIP offers a unique opportunity to answer them.
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Malagnac et al. (2026) studied this question.
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