Non-invasive Brain Stimulation and Light-based Therapies for Sleep Dysregulation in Major Depressive Disorder: Evidence From a Parameter-stratified Network Meta-analysis of Randomized Controlled Trials (P11-14.009)

Muneeb Ahmad Muneer; Amatul Aala; Dawood shah; Rimsha Adnan; Ayesha Amjad; Faris Fayyaz; Ameer Hamza; Areeb Amjad; Muhammad Saleem; Amna Asif; Farid Ullah; Fahad Butt; Prithvi Pillai; Shanza Abbasi; Dabbara V Ramana; SAI VENKATA MANOJ KOTHARU

doi:10.1212/wnl.0000000000213178

June 9, 2026Neurology

Non-invasive Brain Stimulation and Light-based Therapies for Sleep Dysregulation in Major Depressive Disorder: Evidence From a Parameter-stratified Network Meta-analysis of Randomized Controlled Trials (P11-14.009)

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Key Points

The study aims to evaluate the effectiveness of non-invasive brain stimulation (NIBS) techniques and bright light therapy (BLT) on sleep disturbances in patients with major depressive disorder (MDD).
Conducted a network meta-analysis (NMA) of randomized controlled trials (RCTs) comparing NIBS modalities and BLT.
Included multiple interventions focusing on sleep outcomes in MDD.
Analyzed various parameters to assess the efficacy of each modality.
NIBS modalities showed greater improvement in sleep outcomes compared to standard interventions.
Bright light therapy significantly enhanced sleep quality in patients with MDD.
Network meta-analysis demonstrated the relative efficacy among different interventions.

Implication

Randomized trial compares sleep outcomes with NIBS and BLT in major depressive disorder, suggesting effective non-invasive treatments.

Abstract

To compare the efficacy of NIBS modalities and bright light therapy (BLT) on sleep outcomes in MDD using a network meta-analysis (NMA) of randomized controlled trials (RCTs).

Discussion

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Cite This Study

Muneer et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf36efaef96ed7f055db9 https://doi.org/10.1212/wnl.0000000000213178

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Non-invasive Brain Stimulation and Light-based Therapies for Sleep Dysregulation in Major Depressive Disorder: Evidence From a Parameter-stratified Network Meta-analysis of Randomized Controlled Trials (P11-14.009)

Key Points

Implication

Abstract

Discussion

Cite This Study

Non-invasive Brain Stimulation and Light-based Therapies for Sleep Dysregulation in Major Depressive Disorder: Evidence From a Parameter-stratified Network Meta-analysis of Randomized Controlled Trials (P11-14.009)

Key Points

Implication

Abstract

Discussion

Cite This Study

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