Proximal Complement Inhibition in Generalized Myasthenia Gravis (P4-9.002)

Shahar Shelly; Marianna Lalla; Yang Zhao (39052); Linda Rehaume; Jennifer Cross; Tuan Vu

doi:10.1212/wnl.0000000000213003

June 9, 2026Neurology

Proximal Complement Inhibition in Generalized Myasthenia Gravis (P4-9.002)

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Key Points

This research aims to investigate if inhibiting C1s with claseprubart can reduce levels of complement components C3a, C3b, and membrane attack complex in generalized myasthenia gravis.
Utilized claseprubart (DNTH103) to inhibit active C1s and observe effects on complement components.
Compared the complement inhibition profile of claseprubart with the C5 inhibitor ravulizumab.
Claseprubart significantly suppressed the generation of C3a and C3b compared to baseline levels.
The inhibition profile of claseprubart differed from that of ravulizumab, highlighting unique mechanisms of action.

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Implication

Evaluates complement inhibition effects on C3a and C3b generation in myasthenia gravis, indicating potential therapeutic strategies.

Abstract

To determine whether active C1s (aC1s) inhibition by claseprubart (DNTH103) suppresses generation of C3a, C3b and membrane attack complex (MAC), and whether its complement inhibition profile is different to that of the C5 inhibitor ravulizumab.

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Cite This Study

Shelly et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf36efaef96ed7f055efa https://doi.org/10.1212/wnl.0000000000213003

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Proximal Complement Inhibition in Generalized Myasthenia Gravis (P4-9.002)

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Proximal Complement Inhibition in Generalized Myasthenia Gravis (P4-9.002)

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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