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June 9, 2026Neurology

Memantine Improves Neuropsychological Function in Systemic Lupus Erythematosus (P5-2.008)

L. Crofford Lillian Ahmed Jonathan Williams Jillian Rhoads Jana Shirey-Rice Jill Pulley Patrick McGrath Chang Lee James C. Jackson

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Key Points

The aim is to evaluate the effect of memantine on enhancing neuropsychological function in patients with systemic lupus erythematosus.
Study design
Assessments focused on objective neuropsychological function
Population includes individuals diagnosed with systemic lupus erythematosus
Memantine administration leads to measurable improvements in neuropsychological outcomes
Significant enhancements in cognitive function were observed

Implication

Investigates memantine's impact on neuropsychological function in individuals with SLE, suggesting cognitive improvements.

Abstract

Determine if memantine improves objective neuropsychological function in individuals with systemic lupus erythematosus (SLE).

Discussion

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Cite This Study

Crofford et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf36efaef96ed7f055f8d https://doi.org/10.1212/wnl.0000000000215919

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Improvement in neuropsychological function with memantine treatment among patients with systemic lupus erythematosus: a phase 2 randomised placebo-controlled clinical trialHuman Clinical Trial · 2026
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3P147 A study of cognitive dysfunction in patients with systemic lupus erythematosus and to estimate its prevalenceCross-Sectional Study · 2026
4P157 Neurocognitive insights: functional magnetic resonance imaging of spatial working memory and sustained attention in people with systemic lupus erythematous2024
5Memantine for Parkinson’s Disease: Does It Make a Difference? (P3-17.014)Original Research · 2026

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B – 57 Assessment of Cognitive Impairment due to Multiple Etiologies in a Case of Childhood Onset Systemic Lupus Erythematosus2025
A Multidisciplinary Neuro-Lupus Program for the Evaluation and Management of Patients With SLE and Cognitive Concerns2026
Teaching Video NeuroImage: Osmotic Demyelination Syndrome With Appropriate Sodium Correction Causing Isolated Basal Ganglia Demyelination and Reversible ParkinsonismNeurology · 2026
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