Demonstrates enhanced anti-tumor effects using hemoglobin-based nanozyme in glioblastoma cells, indicating potential for targeted cancer treatment.
, were obtained for catalase-like and peroxidase-like activities, respectively. Hb@Ru NPs exhibited ruthenium induced nanomotor behavior which was utilized to enhance the interaction between tumor cells and nanozyme. Photothermal conversion behavior of Hb@Ru NPs was demonstrated with the temperature elevations of up to 29 °C under NIR laser irradiation. Therapeutic potential of Hb@Ru NPs was evaluated using T98G glioblastoma and HepG2 cells. In-vitro combinatorial photothermal/chemodynamic therapy (PTT&CDT) with T98G cells achieved up to 92.7% cell death, with effective intracellular ROS formation and yielded an apoptotic rate of 63.32%, as determined by flow cytometry. TUNEL staining demonstrated that Hb@Ru NPs significantly induced DNA fragmentation in T98G cells by combined PTT&CDT via producing the most pronounced apoptotic response. PTT&CDT with Hb@Ru NPs also suppressed the migration and proliferation of glioblastoma cells, significantly inhibiting the wound closure in stratch assay.
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Çoban et al. (2026) studied this question.
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