Comparative Effects of Pharmacologic Interventions on Subjective and Functional Sleep-Wake Outcomes in Alzheimer’s Disease: A Network Meta-Analysis of Randomized Controlled Trials (P3-13.009)

June 9, 2026Neurology

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Key Points

The aim is to evaluate how different pharmacologic treatments affect sleep-wake parameters in individuals with Alzheimer's disease.
Conducted a network meta-analysis of randomized controlled trials.
Utilized polysomnography and actigraphy to assess sleep-wake parameters.
Analyzed subjective and functional outcomes related to sleep.
Interventions showed varying impacts on subjective sleep quality as measured by standardized scales.
Functional sleep-wake outcomes improved with specific pharmacologic treatments, though exact metrics are not detailed.
Overall efficacy and safety of sleep-related medications remain significant considerations.

Randomized trial assesses pharmacologic effects on sleep-wake outcomes in Alzheimer’s, indicating potential treatment implications.

To assess pharmacologic effects on subjective and functional sleep-wake parameters in Alzheimer’s disease using polysomnography and actigraphy

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Murugan et al. (2026) studied this question.

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