[F-18]PBR06 TSPO-PET Reveals Region-specific Neuroinflammation in Multiple System Atrophy and Relates to Clinical Severity and Brain Atrophy (S33.002)

Steven Cicero; Diego Rodriguez; Alain Ndayisaba; Nicolas Horan; Olivia Laun; Hong Pan; Eero Rissanen; Shipra Dubey; Geoffrey Young; Jisoo Kim; Ashlan Willett; Ariana Pitaro; Howard Weiner; Vikram Khurana; Tarun Singhal

doi:10.1212/wnl.0000000000217287

June 9, 2026Neurology

[F-18]PBR06 TSPO-PET Reveals Region-specific Neuroinflammation in Multiple System Atrophy and Relates to Clinical Severity and Brain Atrophy (S33.002)

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Key Points

This research aims to assess microglial activation in Multiple System Atrophy (MSA) and its correlation with clinical outcomes and brain changes.
Evaluated region-specific microglial activation using [F-18]PBR06 -PET.
Analyzed associations with clinical severity, regional atrophy, and survival.
Identified significant microglial activation in specific brain regions associated with clinical severity.
Observed relationships between neuroinflammation and brain atrophy metrics.

Implication

Evaluates neuroinflammation in Multiple System Atrophy, suggesting links to clinical severity and brain atrophy.

Abstract

To evaluate region-specific microglial activation in Multiple System Atrophy (MSA) using [F-18]PBR06 -PET targeting 18kiloDalton-translocator protein (TSPO) and examine its association with clinical severity, regional atrophy, and survival.

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Cite This Study

Cicero et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3b4faef96ed7f056210 https://doi.org/10.1212/wnl.0000000000217287

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[F-18]PBR06 TSPO-PET Reveals Region-specific Neuroinflammation in Multiple System Atrophy and Relates to Clinical Severity and Brain Atrophy (S33.002)

Key Points

Implication

Abstract

Discussion

Cite This Study

[F-18]PBR06 TSPO-PET Reveals Region-specific Neuroinflammation in Multiple System Atrophy and Relates to Clinical Severity and Brain Atrophy (S33.002)

Key Points

Implication

Abstract

Discussion

Cite This Study

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