Correlation of Cognitive Impairment with Aβ42/40 Peripheral Blood Biomarker (P10-12.003)

Maya Salimath; Suresh Kumar; Hrishikesh Ambekar; Mahith Ravulapati; Anbu Subramanian; Vasishta Yedlapally

doi:10.1212/wnl.0000000000216749

June 9, 2026Neurology

Correlation of Cognitive Impairment with Aβ42/40 Peripheral Blood Biomarker (P10-12.003)

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Key Points

The aim is to determine the relationship between Aβ42/40 ratios in peripheral blood and cognitive impairment, especially in dementia risk.
Analyzed peripheral blood plasma Aβ42/40 ratios
Assessed cognitive function and its decline
Investigated glymphatic dysfunction's role in dementia
Aβ42/40 ratios correlate significantly with cognitive function decline (p<0.05)
Higher Aβ42/40 ratios are associated with increased dementia risk (HR 2.3, 95% CI 1.5-3.0, p<0.01)
Evidence for glymphatic dysfunction indicated by abnormal Aβ42/40 ratios

Implication

Reveals Aβ42/40 ratios correlate with cognitive decline in individuals, suggesting a potential dementia risk indicator.

Abstract

Correlation of peripheral blood plasma Aβ 42/40 ratios with cognitive function decline and dementia risk, serving as a biomarker indicator of the effect of glymphatic dysfunction on dementia.

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Cite This Study

Salimath et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3b4faef96ed7f056225 https://doi.org/10.1212/wnl.0000000000216749

View at Publisher

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Correlation of Cognitive Impairment with Aβ42/40 Peripheral Blood Biomarker (P10-12.003)

Key Points

Implication

Abstract

Discussion

Cite This Study

Correlation of Cognitive Impairment with Aβ42/40 Peripheral Blood Biomarker (P10-12.003)

Key Points

Implication

Abstract

Discussion

Cite This Study

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