Phase 1, Open-label, Fixed-sequence, Bidirectional, Pharmacokinetic (PK) Drug-drug Interaction (DDI) Study Between Cannabidiol (CBD) and Cenobamate (CNB) in Healthy Adult Participants (P11-10.002)

Arjun Vijan; Hongwei Xue; P. Chandler; Sujith Madhavan; Cuiping Chen

doi:10.1212/wnl.0000000000215597

June 9, 2026Neurology

Phase 1, Open-label, Fixed-sequence, Bidirectional, Pharmacokinetic (PK) Drug-drug Interaction (DDI) Study Between Cannabidiol (CBD) and Cenobamate (CNB) in Healthy Adult Participants (P11-10.002)

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Key Points

This study aims to evaluate the pharmacokinetic drug-drug interactions between cannabidiol (CBD) and cenobamate (CNB).
Phase 1, open-label design
Fixed-sequence, bidirectional study
Conducted in healthy adult participants
Data revealing the pharmacokinetic profiles of CBD and CNB were analyzed.
Identified any significant interactions between CBD and CNB in terms of absorption and metabolism.

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Implication

Evaluates pharmacokinetic drug-drug interactions between cannabidiol and cenobamate in healthy adults, suggesting potential implications for combined use.

Abstract

Evaluate PK DDIs between CBD and CNB.

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Cite This Study

Vijan et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3b4faef96ed7f056259 https://doi.org/10.1212/wnl.0000000000215597

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Phase 1, Open-label, Fixed-sequence, Bidirectional, Pharmacokinetic (PK) Drug-drug Interaction (DDI) Study Between Cannabidiol (CBD) and Cenobamate (CNB) in Healthy Adult Participants (P11-10.002)

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Phase 1, Open-label, Fixed-sequence, Bidirectional, Pharmacokinetic (PK) Drug-drug Interaction (DDI) Study Between Cannabidiol (CBD) and Cenobamate (CNB) in Healthy Adult Participants (P11-10.002)

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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