⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

June 9, 2026Neurology

Immunosuppressive Therapies in Down Syndrome Regression Disorder: A Prospective Observational Cohort Study (N2.002)

Jose Santoro Lilia Kazerooni Maeve Lucas Mariam Yousuf Samuel Otey Lina Nguyen Nidhiben Anadani Melanie Manning Angela Rachubinski Ryan Kammeyer Noemi Spinazzi Catherine Franklin Eileen Quinn Joaquin Espinosa Michael Rafii

View at Publisher

Ask AI

Bookmark

Share

Key Points

The study aims to evaluate how effective immunosuppressive therapies are for individuals with Down Syndrome Regression Disorder (DSRD) who respond partially to IVIg.
Prospective observational cohort study design
Focused on individuals with Down Syndrome Regression Disorder
Evaluated the response to immunosuppressive therapies.
Partial responders to IVIg showed variable efficacy with immunosuppressive therapies.
Some improvement in symptoms was noted, but exact metrics were not provided.

Implication

Prospective observational cohort study evaluates immunosuppressive therapies in individuals with DSRD, indicating their potential benefits.

Abstract

This study aimed to evaluate the efficacy of immunosuppressive therapies in individuals with DSRD who were partial responders to IVIg.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Santoro et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3b4faef96ed7f056300 https://doi.org/10.1212/wnl.0000000000213058

View at Publisher

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Safety and Tolerability of Intravenous Immunoglobulin Infusion in Down Syndrome Regression Disorder (P6-8.007)2024
2Immunosuppression in Down syndrome regression disorder: a prospective observational cohort studyCohort Study · 2026
3Case report: Down syndrome regression disorder, catatonia, and psychiatric and immunomodulatory interventions2024 · 3 citations
4Neuroimaging abnormalities associated with immunotherapy responsiveness in Down syndrome regression disorder2024 · 16 citations
5Case Report: Improvement Following Immunotherapy in an Individual With Seronegative Down Syndrome Disintegrative DisorderCase Report · 2021 · 25 citations

More related papers

A Comparative Effectiveness Study of Lorazepam or IVIg Versus no Treatment for Down Syndrome Regression Disorder2026
Neuroimaging Abnormalities Predict Immunotherapy Responsiveness in Down Syndrome Regression Disorder (S37.009)2024
How I Treat: Immune dysregulation in Down syndrome2026

More from Neurology

Role of APOE ɛ4 and ɛ2 With Longitudinal Cognitive Decline Among Those With Exceptional LongevityFri,
Associations of Antibodies Against Several Infections With Alzheimer Disease NeuropathologyFri,