Greater clinical benefit with tiomolibdate choline versus standard-of-care in neurologic WD patients in the Phase 3 FoCus Trial (LS1.008)

Aurélia Poujois; Jeff Bronstein; Matthew Lorincz; Peter Hedera; Danny Bega; Chandler Robinson; Andrew Cittadine; Declan Tuffy; Petr Dusek; Isabelle Mohr; Tomasz Litwin

doi:10.1212/wnl.0000000000217901

June 9, 2026Neurology

Greater clinical benefit with tiomolibdate choline versus standard-of-care in neurologic WD patients in the Phase 3 FoCus Trial (LS1.008)

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Key Points

This research aims to assess the efficacy of tiomolibdate choline in improving neurologic and clinical outcomes in patients with Wilson disease.
Phase 3 trial comparing tiomolibdate choline with standard-of-care
Participants included Wilson disease patients with neurologic symptoms
Clinical and neurologic outcomes were evaluated during the trial.
Tiomolibdate choline showed significant improvement in neurologic outcomes compared to standard-of-care
Enhanced clinical benefit was noted for patients receiving tiomolibdate choline versus standard treatment.

Implication

Evaluates tiomolibdate choline versus standard-of-care in Wilson disease patients, showing improved neurologic outcomes.

Abstract

To evaluate the neurologic and clinical outcomes of tiomolibdate choline (TMC) compared with standard-of-care (SoC) in Wilson disease (WD) patients with neurologic symptoms.

Discussion

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Cite This Study

Poujois et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3b4faef96ed7f05631a https://doi.org/10.1212/wnl.0000000000217901

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Greater clinical benefit with tiomolibdate choline versus standard-of-care in neurologic WD patients in the Phase 3 FoCus Trial (LS1.008)

Key Points

Implication

Abstract

Discussion

Cite This Study

Greater clinical benefit with tiomolibdate choline versus standard-of-care in neurologic WD patients in the Phase 3 FoCus Trial (LS1.008)

Key Points

Implication

Abstract

Discussion

Cite This Study

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