Enhancer Dysregulation in ALS: Evidence for Noncoding Regulatory Mechanisms in Neuronal Inflammation and Apoptosis (S2.004)

Guillermo Pons Monnier; Nerea Martin del Campo; Miranda de la Pena-Tamez; Oscar Gutierrez Trevino; Emmanuel Martínez-Ledesma; Raquel Cuevas‐Díaz Durán; Hector Martinez

doi:10.1212/wnl.0000000000215211

June 9, 2026Neurology

Enhancer Dysregulation in ALS: Evidence for Noncoding Regulatory Mechanisms in Neuronal Inflammation and Apoptosis (S2.004)

View at Publisher

Ask AI

Bookmark

Share

Key Points

This research aims to explore the role of SNPs in enhancer regions related to ALS and their impact on neuronal cell death.
Investigated SNPs associated with ALS located in active enhancer regions.
Examined the relationship between these SNPs and genetic dysregulation.
Analyzed effects on neuronal inflammation and apoptosis.
Identified specific SNPs that significantly contribute to genetic dysregulation.
Confirmed associations between enhancer dysregulation and increased neuronal cell death.
Highlighted the impact of noncoding regulatory mechanisms in ALS.

Implication

Investigates SNPs linked to ALS and their role in neuronal cell death, suggesting new insights into genetic mechanisms.

Abstract

To determine whether single nucleotide polymorphisms (SNPs) associated with amyotrophic lateral sclerosis (ALS) and located within active enhancer regions contribute to genetic dysregulation and neuronal cell death.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Monnier et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3d6faef96ed7f056421 https://doi.org/10.1212/wnl.0000000000215211

View at Publisher

Ask AI

Bookmark

Share

Enhancer Dysregulation in ALS: Evidence for Noncoding Regulatory Mechanisms in Neuronal Inflammation and Apoptosis (S2.004)

Key Points

Implication

Abstract

Discussion

Cite This Study

Enhancer Dysregulation in ALS: Evidence for Noncoding Regulatory Mechanisms in Neuronal Inflammation and Apoptosis (S2.004)

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

More related papers

More from Neurology

Keep reading

More related papers

More from Neurology