Choroid Plexus Enlargement in Multiple Sclerosis: Normative Trajectories, Clinical Correlates, and Genetic Associations (P5-19.003)

Paolo Preziosa; Gianluca Corazzolla; Alessandro Meani; Monica Margoni; Loredana Storelli; Elisabetta Pagani; Martina Rubin; Ferdinando Clarelli; Elisabetta Mascia; Melissa Sorosina; Federica Esposito; Maria Rocca; Massimo Filippi

doi:10.1212/wnl.0000000000213046

June 9, 2026Neurology

Choroid Plexus Enlargement in Multiple Sclerosis: Normative Trajectories, Clinical Correlates, and Genetic Associations (P5-19.003)

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Key Points

This research aims to identify choroid plexus volume patterns in healthy individuals and evaluate their relevance in multiple sclerosis patients.
Defined normative volume trajectories of the choroid plexus across the lifespan.
Calculated z-scores for choroid plexus volume in multiple sclerosis patients.
Assessed associations with demographic, clinical, MRI, and genetic variables, including HLA and non-HLA PRS.
Identified normative choroid plexus volume trajectories in healthy participants.
Established significant associations between choroid plexus volume and clinical features in multiple sclerosis patients.
Noted genetic correlations with HLA and polygenic risk scores affecting choroid plexus volume.

Implication

Study defines choroid plexus volume changes in multiple sclerosis, indicating potential clinical importance.

Abstract

To define normative choroid plexus (ChP) volume trajectories across the healthy lifespan and compute z-scores in multiple sclerosis (MS) patients, evaluating associations with demographic, clinical, MRI, and genetic variables, including Human Leukocyte Antigen (HLA) and non-HLA polygenic risk scores (PRS).

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Cite This Study

Preziosa et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3d6faef96ed7f0564ee https://doi.org/10.1212/wnl.0000000000213046

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Choroid Plexus Enlargement in Multiple Sclerosis: Normative Trajectories, Clinical Correlates, and Genetic Associations (P5-19.003)

Key Points

Implication

Abstract

Discussion

Cite This Study

Choroid Plexus Enlargement in Multiple Sclerosis: Normative Trajectories, Clinical Correlates, and Genetic Associations (P5-19.003)

Key Points

Implication

Abstract

Discussion

Cite This Study

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