Real-world Evidence of Longevity of BoNT/A in Cervical Dystonia (RELY-CD) - Long-term Dose–effect Outcomes with Complex-free vs Complex-containing Botulinum Toxin Type A (P7-16.012)

Phillipp Albrecht; Benjamin Waeschle; John‐Ih Lee; Stanisław Ochudło; Małgorzata Tyślerowicz; S Sánchez Valiente; E. López Valdés; Georg Comes; Holger Stark

doi:10.1212/wnl.0000000000216845

June 9, 2026Neurology

Real-world Evidence of Longevity of BoNT/A in Cervical Dystonia (RELY-CD) - Long-term Dose–effect Outcomes with Complex-free vs Complex-containing Botulinum Toxin Type A (P7-16.012)

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Key Points

The aim is to compare the dose-effect outcomes of complex-free and complex-containing botulinum toxin A in cervical dystonia patients over time.
Compared outcomes in patients treated with complex-free versus complex-containing botulinum toxins.
Evaluated dose-effect at year 7 and year 2 to assess treatment longevity.
A higher proportion of patients treated with complex-containing toxins experienced worsening in dose-effect at year 7 compared to year 2.
Specific event rates, effect sizes, and p-values were not provided.

Implication

Compares dose-effect over 7 years in cervical dystonia patients treated with botulinum toxin A.

Abstract

To compare the proportion of cervical dystonia (CD) patients treated exclusively with complex-free (incobotulinumtoxinA; CF) or complex-containing (onabotulinumtoxinA or abobotulinumtoxinA; CC) botulinum toxin type A who experienced a worsening in dose–effect (DEff) at year 7 versus year 2.

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Cite This Study

Albrecht et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3d6faef96ed7f056518 https://doi.org/10.1212/wnl.0000000000216845

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Real-world Evidence of Longevity of BoNT/A in Cervical Dystonia (RELY-CD) - Long-term Dose–effect Outcomes with Complex-free vs Complex-containing Botulinum Toxin Type A (P7-16.012)

Key Points

Implication

Abstract

Discussion

Cite This Study

Real-world Evidence of Longevity of BoNT/A in Cervical Dystonia (RELY-CD) - Long-term Dose–effect Outcomes with Complex-free vs Complex-containing Botulinum Toxin Type A (P7-16.012)

Key Points

Implication

Abstract

Discussion

Cite This Study

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