Diagnostic Pitfalls in CADASIL: MRI Red Flags and Variant Interpretation Across Three Adults (P1-4.010)

Yasho Gondi; Mohanad Ahmad; Omar Hage‐Hassan; Aisha Siddiqui; Farah Abdelhak; Karen Krajewski; Kashiff Ariff; Kumar Rajamani

doi:10.1212/wnl.0000000000215021

June 9, 2026Neurology

Diagnostic Pitfalls in CADASIL: MRI Red Flags and Variant Interpretation Across Three Adults (P1-4.010)

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Key Points

This research aims to identify clinical characteristics and diagnostic challenges in CADASIL cases misinterpreted as other conditions.
Evaluated three adults suspected of CADASIL
Analyzed clinical features and MRI findings
Highlighted genetic test interpretations
MRI red flags were identified indicating possible misdiagnoses
Genetic findings revealed variants associated with CADASIL
Clinical presentations overlapped with symptoms of epilepsy and multiple sclerosis

Implication

Case descriptions highlight MRI red flags and diagnostic pitfalls in CADASIL mimicking epilepsy or multiple sclerosis.

Abstract

To describe the clinical features, MRI “red flags,” and genetic findings of three adults evaluated for suspected CADASIL and to highlight diagnostic pitfalls that mimic epilepsy or multiple sclerosis.

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Cite This Study

Gondi et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3d6faef96ed7f056547 https://doi.org/10.1212/wnl.0000000000215021

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Diagnostic Pitfalls in CADASIL: MRI Red Flags and Variant Interpretation Across Three Adults (P1-4.010)

Key Points

Implication

Abstract

Discussion

Cite This Study

Diagnostic Pitfalls in CADASIL: MRI Red Flags and Variant Interpretation Across Three Adults (P1-4.010)

Key Points

Implication

Abstract

Discussion

Cite This Study

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