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June 9, 2026Neurology

Cobalamin Transporter Antibody-associated Ataxia and Longitudinal Posterior Column Myelopathy: A Diagnostic Challenge (P8-2.011)

Kaila Anderson Laura Grezzo John Pluvinage Mark Wilson Sarah Berman Cigdem Isitan-Alkawadri Jenny Linnoila

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Key Points

To highlight a connection between anti-CD320 antibodies and a unique neurological syndrome despite normal vitamin B12 levels.
Descriptive case analysis of a patient with progressive symptoms.
Initial evaluations showed normal vitamin B12 levels and nondiagnostic results for myelopathy.
Focus on the presence of anti-CD320 antibodies.
Identified a progressive syndrome of cerebellar ataxia and spinal cord dysfunction.
Anti-CD320 antibodies were present despite normal vitamin B12 levels.
The findings underscore diagnostic challenges in such cases.

Implication

Case report describes progressive ataxia and myelopathy linked to anti-CD320 antibodies, suggesting diagnostic complexities.

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Cite This Study

Anderson et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf403faef96ed7f05664d https://doi.org/10.1212/wnl.0000000000217670

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Anti-CD320 Autoantibodies and Central Nervous System Vitamin B <sub>12</sub> Deficiency in Idiopathic MyelopathyCohort Study · 2026
2Rapidly Progressive Dementia Secondary to Vitamin B12 Deficiency: A Case ReportCase Report · 2026
3Resolution of acute cerebellar ataxia with vitamin B12 supplementation in a 19-year-old female with normal vitamin B12 levels2024
4Subacute combined degeneration of the spinal cord with cerebellar lesions: A case report2024 · 4 citations
5Case Report: Subacute combined degeneration of the spinal cord mimic accompanying adaptor protein-3B2-IgG2025 · 1 citations