“Todd’s Pupil” Sign: Persistent Episodic Unilateral Mydriasis as a Diagnostic Clue to Coexisting Epilepsy in Psychogenic Non-epileptic Seizures (P5-10.004)

Daniel Moreno-Zambrano; Chala Riddick; Syed Naqvi; Vanesa Webb-Barragan; Carlos Oliu

doi:10.1212/wnl.0000000000216939

June 9, 2026Neurology

“Todd’s Pupil” Sign: Persistent Episodic Unilateral Mydriasis as a Diagnostic Clue to Coexisting Epilepsy in Psychogenic Non-epileptic Seizures (P5-10.004)

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Key Points

The study aims to explore a new diagnostic sign that indicates coexisting epilepsy in cases of PNES.
Descriptive case study of a patient with persistent unilateral mydriasis.
Evaluation of the relationship between Todd’s pupil sign and epilepsy in PNES.
The Todd’s pupil sign was identified as a significant indicator of coexisting epilepsy.
The patient demonstrated persistent episodic unilateral mydriasis associated with psychogenic seizures.

Implication

This case describes how a unique pupil sign signals epilepsy in individuals with psychogenic non-epileptic seizures.

Abstract

To describe a novel “Todd’s pupil” sign in a rare case of persistent Episodic Unilateral Mydriasis (EUM), indicating coexisting Epilepsy in Psychogenic Non-Epileptic Seizures (PNES).

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Cite This Study

Moreno-Zambrano et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf403faef96ed7f056657 https://doi.org/10.1212/wnl.0000000000216939

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“Todd’s Pupil” Sign: Persistent Episodic Unilateral Mydriasis as a Diagnostic Clue to Coexisting Epilepsy in Psychogenic Non-epileptic Seizures (P5-10.004)

Key Points

Implication

Abstract

Discussion

Cite This Study

“Todd’s Pupil” Sign: Persistent Episodic Unilateral Mydriasis as a Diagnostic Clue to Coexisting Epilepsy in Psychogenic Non-epileptic Seizures (P5-10.004)

Key Points

Implication

Abstract

Discussion

Cite This Study

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