Atroposelective Synthesis of Axially Chiral Conjugated Dienes via Pd-Catalyzed Regio- and E -Selective Hydroalkenylation of Allene

The conjugated dienes are valuable intermediates in organic synthesis and also found in natural products and pharmaceuticals. However, the efficient construction of conjugated dienes bearing a chiral axis remains challenging and underdeveloped. Herein, we disclosed a palladium-catalyzed highly regio-, E -, and atroposelective hydroalkenylation of allene providing a series of conjugated dienes bearing a chiral C–N or C–C axis with high functional group tolerance. Notably, this method also provides a new platform for the design and construction of novel axially chiral diene–phosphine ligands.