What question did this study set out to answer?

This research aims to develop an eco-friendly and highly sensitive method for detecting N-nitroso dorzolamide in drug substances and formulations.

June 13, 2026Separation Science Plus

Eco‐Friendly and Highly Sensitive Liquid Chromatography Mass Spectrometric Method for Trace Level Quantification of N ‐Nitroso Dorzolamide in Dorzolamide Drug Substance and Ophthalmic Formulations

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Authors

AKAnwar Sulaiman KCREVA University KRK. Ramakrishna ReddyREVA University

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Implication

Randomized trial demonstrates a highly sensitive method for quantifying N-nitroso dorzolamide in ophthalmic products, indicating improved pharmaceutical quality assurance.

Key Points

This research aims to develop an eco-friendly and highly sensitive method for detecting N-nitroso dorzolamide in drug substances and formulations.
Innovative liquid chromatography-mass spectrometry method with negative electrospray ionization.
Validation according to ICH Q2(R2) standards, with a detection limit of 0.03 µg/g.
Environmental assessment using Green Analytical Procedure Index and other eco-analysis tools.
Achieved excellent linearity (R² > 0.999) and high precision in method validation.
Confirmed compliance with regulatory requirements in commercial dorzolamide formulations.
Demonstrated significant environmental advantages over traditional analytical methods.

Cite This Study

KC et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf41ffaef96ed7f0567b6 https://doi.org/10.1002/sscp.70263

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Implication

Randomized trial demonstrates a highly sensitive method for quantifying N-nitroso dorzolamide in ophthalmic products, indicating improved pharmaceutical quality assurance.

Eco‐Friendly and Highly Sensitive Liquid Chromatography Mass Spectrometric Method for Trace Level Quantification of N ‐Nitroso Dorzolamide in Dorzolamide Drug Substance and Ophthalmic Formulations

Discussion

Member takes

Implication

Key Points

Cite This Study

Eco‐Friendly and Highly Sensitive Liquid Chromatography Mass Spectrometric Method for Trace Level Quantification of N ‐Nitroso Dorzolamide in Dorzolamide Drug Substance and Ophthalmic Formulations

Discussion

Member takes

Implication

Key Points

Cite This Study

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