2120-P: Perioperative Automated Insulin Delivery (AID) Use in Youth and Young Adults (YYA)

Introduction and Objective: Continuous glucose monitors (CGMs) and AID systems significantly improve glycemic control. As CGMs lack hospital indication, pediatric perioperative practices often disable automation for procedures under anesthesia. We compared glycemic outcomes in YYA with and without automation use. Methods: YYA using AID systems undergoing procedures with anesthesia were enrolled in a prospective study. Continuation of automation was determined by the patient and anesthesia team. CGM data was collected for standard glycemic metrics with between-group comparisons analyzed (Figure). Results: Of 26 procedures (mean age 12.6±4.3y, 61% female), 11 continued automation. The automated group had significantly lower average blood glucose during the pre- and intraoperative periods (135.5 vs 185.2 mg/dL and 134.8 vs 168.9 mg/dL, respectively, p<0.05). While TIR (70-180mg/dL) was higher in the automation group, it did not reach significance. Hypoglycemia (<70mg/dL) was also not significantly different between groups. (Figure). Conclusion: Perioperative use of automation improves glucose levels without increased hypoglycemia, suggesting that AID can be safe and effective during procedures under anesthesia. The study is ongoing to explore the effects of perioperative medications, CGM accuracy, and glycemic outcomes in a larger cohort. Disclosure A.J. Karami: None. E. Fivekiller: None. L. Geiser: None. M. Hoagland: None. A.M. Jaeger: None. S. Lange: None. A.B. Stein: None. B. Stewart: None. K. Taylor: None. E. Cobry: None.