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Demonstrates reduced liver failure post-hepatectomy in patients using tranexamic acid, suggesting a new treatment option.
Pharmacological plasminogen reduction enhanced liver regeneration experimentally and clinically. siRNA-induced plasminogen deficiency promoted hepatocyte proliferation after partial hepatectomy in mice, contrasting genetic deficiency models. In the HeLiX trial, tranexamic acid reduced post-hepatectomy liver failure odds, suggesting a novel therapeutic strategy.
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Li et al. (2026) studied this question.
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