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June 11, 2026Clinical Kidney JournalOpen Access

Hypomagnesemia in Patients on Oral EGFR Tyrosine Kinase Inhibitors: Renal Magnesium Wasting or Concurrent Confounders?

Maria Ilyas Jacqueline Nguyen Shruti Shettigar Kanika Rathi E G Kim Jake LeClaire Akash Mathavan A Mathavan Aline Fares Chintan V. Shah

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Key Points

This research aims to investigate the mechanisms behind hypomagnesemia in patients receiving oral EGFR tyrosine kinase inhibitors.
Enrolled patients on oral EGFR tyrosine kinase inhibitors.
Measured serum magnesium levels and renal magnesium excretion over a defined follow-up period.
Analyzed potential confounding factors affecting magnesium levels.
Findings indicated a significant increase in renal magnesium wasting among patients (p<0.05).
Identified that concurrent medications also influenced magnesium levels, with a correlation coefficient of 0.75 (p=0.01).
Observed a 20% higher incidence of hypomagnesemia in patients treated with certain additional therapies.

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Implication

Examines the causes of hypomagnesemia in patients, suggesting underlying renal issues or other factors.

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Cite This Study

Ilyas et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf45afaef96ed7f056a1e https://doi.org/10.1093/ckj/sfag203

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Hypomagnesemia as a predictor of the efficacy of combination EGFR-targeted drugs versus EGFR ADCs alone in HNSCC.2024
2The Clinical Spectrum of Acquired Hypomagnesemia: From Etiology to Therapeutic Approaches2025 · 12 citations
3Renal magnesium wasting and functional hypoparathyroidism: a diagnostic and therapeutic challenge in hypocalcemiaOriginal Research · 2026
4Hypomagnesaemia in Renal Transplant Recipients: A Review of Mechanistic Complexity, Diagnostic Gaps, and Emerging Therapeutic Strategies2025 · 2 citations
5Risk of hypermagnesemia in patients with eating disorders taking magnesium oxide preparations: a retrospective study2025

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