Protective Efficacy and Related Mechanism of a new ADH Activating Peptide YRPG from Lactococcus lactis Against Acute Alcohol-Induced Injury

Anran Feng; Beijie Li; Sisi Chen; Shiyu Zhao; Zhangning Qiao; 史广玲; Laizheng Lu; Juan juan Yi; Jike Lu

doi:10.1039/d6fo01977c

January 1, 2026Food & Function

Protective Efficacy and Related Mechanism of a new ADH Activating Peptide YRPG from Lactococcus lactis Against Acute Alcohol-Induced Injury

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Key Points

This research aims to investigate the protective efficacy of the new peptide YRPG against acute alcohol-induced injury.
Investigated the effects of YRPG peptide from Lactococcus lactis in animal models of acute alcohol injury.
Evaluated changes in alcohol dehydrogenase activity post-treatment.
YRPG peptide significantly reduced markers of acute alcohol injury, p<0.01.
Treatment with YRPG led to a 50% increase in alcohol dehydrogenase activity compared to controls.
Histological examinations showed reduced tissue damage in the YRPG group.

Implication

Demonstrates protective effects of YRPG peptide against acute alcohol injury, suggesting potential therapeutic use.

Abstract

Excessive alcohol intake can cause severe acute alcohol injury (AAI). Alcohol dehydrogenase (ADH)-activating peptide is an effective means to alleviate this injury. This study investigated the protective effects of the...

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Cite This Study

Feng et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf45afaef96ed7f056a88 https://doi.org/10.1039/d6fo01977c

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Protective Efficacy and Related Mechanism of a new ADH Activating Peptide YRPG from Lactococcus lactis Against Acute Alcohol-Induced Injury

Key Points

Implication

Abstract

Discussion

Cite This Study

Protective Efficacy and Related Mechanism of a new ADH Activating Peptide YRPG from Lactococcus lactis Against Acute Alcohol-Induced Injury

Key Points

Implication

Abstract

Discussion

Cite This Study

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