Reversible One-Step Acylation Facilitates Mitochondrial Delivery of Functional RNA

Yuli Zhuang; Xia Liu; Yuxuan Shen; Qiuyue Wang; Zhimin Lin; Qian Zeng; Xin Chen; Linye Jiang; Shao Yao; Jingyan Ge

doi:10.1039/d6sc01497f

January 1, 2026Chemical ScienceOpen Access

Reversible One-Step Acylation Facilitates Mitochondrial Delivery of Functional RNA

View Full Paper

Ask AI

Bookmark

Share

Key Points

The aim is to enhance the delivery and stability of RNA therapeutics targeted for mitochondria.
Developed a reversible one-step acylation method for RNA modification.
Evaluated the efficacy of acylated RNA in cellular models.
Compared the performance of acylated RNA against conventional RNA delivery methods.
Acylated RNA showed significantly improved stability compared to unmodified RNA.
Enhanced mitochondrial uptake was observed with an increase in functional delivery rates.
The method demonstrated promising potential for treating mitochondrial disorders and cancer.

Implication

Investigates mitochondrial delivery of RNA therapeutics, suggesting improved treatment for disorders.

Abstract

Mitochondria-targeted RNA therapeutics hold promise for treating mitochondrial disorders and cancer, yet effective mitochondrial gene modulation remains challenging due to the strong negative charge and intrinsic instability of RNA, which...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Zhuang et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf488faef96ed7f056c02 https://doi.org/10.1039/d6sc01497f

View Full Paper

Ask AI

Bookmark

Share

Reversible One-Step Acylation Facilitates Mitochondrial Delivery of Functional RNA

Key Points

Implication

Abstract

Discussion

Cite This Study

Reversible One-Step Acylation Facilitates Mitochondrial Delivery of Functional RNA

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading