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June 13, 2026ChemSusChem

Selective Biocatalytic Michael Addition Reactions

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Authors

RWRoland Wohlgemuth

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Overview

Biocatalytic Michael addition reactions enhance carbon–carbon bond formation in an ecofriendly manner, indicating a shift towards sustainable chemistry.

Key Points

  • This research aims to explore and enhance the efficiency of biocatalytic Michael addition reactions for sustainable synthesis.
  • Utilized various nucleophiles and activated olefins in biocatalytic Michael addition reactions.
  • Focused on achieving diastereoselective and enantioselective outcomes.
  • Emphasized high atom economy and sustainability in synthetic routes.
  • Successfully demonstrated biocatalytic Michael additions can replace complex multi-step synthetic routes.
  • Achieved significant selectivity in the formation of carbon–carbon bonds.
  • Highlighted the efficiency and eco-friendliness of the one-step biocatalytic process.

Cite This Study

Roland Wohlgemuth (2026) studied this question.

synapsesocial.com/papers/6a2cf488faef96ed7f056ca1https://doi.org/10.1002/cssc.202502620
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Catalytic Strategies for Amide‐Based Michael Additions: Advances and Perspectives2026
  2. 2Diverse Applications and Eco-Friendly Catalysts for Michael Addition Reaction2024
  3. 3Current Developments in Michael Addition Reaction using Heterocycles as Convenient Michael Donors2024 · 13 citations
  4. 4Biocatalytic Asymmetric Michael Addition of Thiols to α,β‐Unsaturated Aldehydes via Enzyme‐Bound Iminium Ion Intermediates2026 · 1 citations
  5. 5Dipeptide-catalysed Michael reaction under physiological conditions: Examination of potential bioorthogonality2024