2077-P: Exposure to Maternal Overnutrition In Utero and Offspring Abdominal and Hepatic Fat Trajectories

Introduction and Objective: The impact of early life exposure to overnutrition on metabolically adverse body fat distribution patterns in childhood is under-studied. Our objective was to examine associations between markers of maternal overnutrition during pregnancy (maternal pre-pregnancy BMI ppBMI, fasting glucose FG and triglycerides TG levels) with offspring abdominal and hepatic fat trajectories. Methods: Data were from 433 mother-child pairs in the Colorado Healthy Start Study, a longitudinal pre-birth cohort. Abdominal visceral and subcutaneous adipose tissue (VAT and SAT) areas and hepatic fat fraction (HF) were assessed by MRI in early childhood (~5 y), mid childhood (~9 y), and adolescence (~12 y). Linear mixed models were used to examine associations of maternal ppBMI, FG, and TG during pregnancy with differences in offspring adiposity trajectories. Results: Mean values for all adiposity measures increased from early childhood (HF: 1.9%, SAT: 47 cm2, VAT: 12 cm2) through adolescence (HF: 2.3%, SAT: 150 cm2, VAT: 29 cm2). Maternal ppBMI and FG were associated with higher offspring SAT, VAT, and HF at nearly all visits in childhood and adolescence, with the strongest effect sizes in adolescence; whereas, maternal TG was primarily associated with higher offspring HF, with the strongest effect size in early childhood (Table 1). Conclusion: Overnutrition in utero may be an important risk factor for adverse adiposity outcomes in offspring. Disclosure C.C. Cohen: None. E.K. Englund: None. J. Giles: None. D. Glueck: None. M. Kelsey: Research Support; Current; Rhythm Pharmaceuticals, Inc. D. Dabelea: None. Funding National Institutes of Health (K99DK136503, R01DK133235)